LIGAND-BASED PREDICTION OF HERG-MEDIATED CARDIOTOXICITY BASED ON THE INTEGRATION OF DIFFERENT MACHINE LEARNING TECHNIQUES

Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques

Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions with the cardiac human-ether-a-go-go-related (hERG) potassium channel.Therefore, prioritizing drug candidates based on their hERG blocking potential is Famil-E a mandatory step in the early pre

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