Ligand-based prediction of hERG-mediated cardiotoxicity based on the integration of different machine learning techniques
Drug-induced cardiotoxicity is a common side effect of drugs in clinical use or under postmarket surveillance and is commonly due to off-target interactions with the cardiac human-ether-a-go-go-related (hERG) potassium channel.Therefore, prioritizing drug candidates based on their hERG blocking potential is Famil-E a mandatory step in the early pre